Why the study?
Does amiodarone increase the British corrected ratio of prothrombin times in rabbits on steady-state warfarin?
Population
New Zealand white rabbits treated with sodium warfarin to a steady British corrected ratio of prothrombin…
Comparison
Amiodarone chloride solution 35 mg given in… vs Baseline (before amiodarone addition)
Design
Preclinical
Follow-up
4 days
Authors
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Amiodarone potentiates warfarin in rabbits; leaves open whether this interaction affects human dosing or bleeding risk.
Does amiodarone increase the British corrected ratio of prothrombin times in rabbits on steady-state warfarin?
Amiodarone significantly potentiates the anticoagulant effect of warfarin, leading to a striking increase in prothrombin time and risk of hemorrhage.
Bannan et al. (1981) studied this question.
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