Key result
In uremic patients with preserved left ventricular ejection fraction, global work efficiency was significantly reduced compared to healthy controls, yielding an AUC of 0.966 for detecting impaired myocardial function.
Why the study?
Cardiac damage is the leading cause of death in uremic patients, prompting evaluation of non-invasive myocardial work index by echocardiography to assess left ventricular systolic function.
Does non-invasive myocardial work index (NIMWI) by echocardiography accurately identify impaired left ventricular myocardial function in uremic patients with preserved LVEF?
Cross-Sectional (n=53)
No
Does non-invasive myocardial work index (NIMWI) by echocardiography accurately identify impaired left ventricular myocardial function in uremic patients with preserved LVEF?
Non-invasive myocardial work index, specifically global work efficiency (GWE), provides a highly sensitive and specific echocardiographic method for early detection of subclinical left ventricular dysfunction in uremic patients with preserved ejection fraction.
Answers are grounded in this paper and cite their sources.
GWE may support early detection of subclinical LV dysfunction in uremic patients with preserved LVEF; hypothesis-generating and requires prospective validation.
BACKGROUND: Cardiac damage is the leading cause of death in uremic patients. This study aimed to evaluate the application of non-invasive myocardial work index (NIMWI) by echocardiography in assessing the left ventricular (LV) systolic function in uremic patients. METHODS: Twenty-six uremic patients and 27 age- and sex-matched healthy volunteers were enrolled in the study. Except for the conventional echocardiographic parameters, the LV myocardial work (MW) parameters including GWI (myocardial global work index), GCW (global constructive work), GWW (global wasted work), and GWE (global work efficiency) were calculated in study participants. Differences in MW parameters between the uremic and normal groups were compared by independent-sample t-test. Receiver operating characteristic (ROC) curves were constructed for MW parameters to detect abnormal LV systolic function in uremic patients. RESULTS: Compared with the normal group, GWW was significantly increased and GWE decreased in the uremic group (P < 0.05). Area under the curve (AUC) for GWE by the ROC analysis was 0.966. The best threshold, sensitivity and specificity values of GWE to detect abnormality of LV systolic function in uremic patients were 92.5%, 0.89 and 0.96, respectively. CONCLUSIONS: NIMWI may be applied to assess the global MW of uremic patients. The presence of reduced GWE can help identify impaired left ventricular myocardial function in uremic patients with preserved LV ejection fraction with a high sensitivity and specificity.
No takes yet. Share an insight, caveat, or question.
Zhu et al. (2022) conducted a cross-sectional in Uremia with preserved left ventricular ejection fraction (n=53). Uremia vs. Healthy volunteers was evaluated on Global work efficiency (GWE) (AUC 0.966, p=<0.001). In uremic patients with preserved left ventricular ejection fraction, global work efficiency was significantly reduced compared to healthy controls, yielding an AUC of 0.966 for detecting impaired myocardial function.
Synapse has enriched 10 related papers. Consider them for comparative context: