Key result
Knockdown of CXCR4 and CXCR7 in hiPSC-CMs demonstrated distinct and sometimes opposing roles in cardiac lineage specification, maturation, and β-adrenergic response.
Population
human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) and engineered cardiac tissues
Comparison
Lentiviral vector-mediated knockdown of CXCR4… vs Control (unmodified) hiPSC-CMs
Design
Preclinical
Authors
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hiPSC data reveal distinct CXCR4/CXCR7 roles in cardiomyocyte function; leaves open in vivo validation for cardiac regeneration.
CXCR4 and CXCR7 have distinct and sometimes opposing roles in the specification, maturation, and functional β-adrenergic response of hiPSC-derived ventricular cardiomyocytes.
Ceholski et al. (2017) studied Cardiac lineage specification and pharmacologic β-adrenergic response. Knockdown of CXCR4 and/or CXCR7 vs. Control (undepleted cells) was evaluated on Cardiac lineage differentiation, calcium transients, and β-adrenergic response. Knockdown of CXCR4 and CXCR7 in hiPSC-CMs demonstrated distinct and sometimes opposing roles in cardiac lineage specification, maturation, and β-adrenergic response.
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