Relieving the strain: The rhodium(I)-catalyzed activation of C-C bonds in functionalized cyclobutanes opens a novel route to highly substituted carbo- and heterocycles. Particularly intriguing is the differentiation of enantiotopic C-C bonds, which leads to the formation of highly enantiomerically enriched lactones, cyclopentanones, and cyclohexenones (see scheme).
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Winter et al. (2009) studied this question.
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