In investigating the solvent action of bile salts on "pneumococci" it was found that sodium desoxycholate is ten times as active, in this respect, as sodium cholate, or commercial sodium taurocholate. The remarkable activity of the desoxycholate in this connection makes its introduction into bacteriological technique desirable, and, as it is possible that the salt may also prove to be of value in the prevention and treatment of local pneumo- coccal infections, it appears to be worth while to place on record a method of preparation of desoxycholic acid which seems to offer certain advantages over those at present in use. The method is in part suggested by the recent work of Wieland and Sorge [1916] who have shown conclusively that the
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W Mair (1917) studied this question.