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Synthetic somatotropin-release inhibiting factor (10ng/ml) decreased significantly basal level of cyclic AMP concentration and showed marginal inhibition of GH release in rat anterior pituitary gland in vitro. Higher dose of synthetic somatotropinrelease inhibiting factor was needed to produce significant inhibition of GH release from the gland. Results obtained in the experiments suggest that somatotropin-release inhibiting factor as well as hypothalamic releasing hormones may act through adenyl cyclase-cyclic AMP system in the anterior pituitary gland.
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Kaneko et al. (1973) studied this question.
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