Effects of Veratrine and Cocaine on Cerebral Carbohydrate-Amino Acid Interrelations

This is the authors' abstract. We don't add key points for this paper.

The rate of aerobic transformation of glucose-U-C(14) into radioactive amino acids by slices of rat-brain cortex is greatly influenced by the K(+)/Ca(++) ratio in the incubating medium. Protoveratrine has effects on the amino acid pattern resembling that due to an increase in the K(+)/Ca(++) ratio. These effects are antagonized by cocaine and may be correlated with the neurophysiological activities of these drugs.