The in vitro release of FSH from rat pituitary glands, when stimulated by a specific releasing factor, viz., follicle-stimulating hormone releasing factor (FRF), or nonspecific factors such as cyclic 3′,5′-AMP (cAMP), or high [K+] medium, required the presence of Ca++ in the external medium. Ca++ together with cAMP probably plays an active intracellular role in the processes leading to the release of FSH. No definite conclusion can be made as to the requirement for Mg++ in these processes. The synthesis (or activation) of FSH, observed during incubation in the presence of FRF, was also Ca++ dependent. However, further experiments are necessary in order to find out whether the presence of Ca++ is required directly for the synthesis of FSH, or whether the synthesis is only a secondary phenomenon arising from the release of FSH. In the latter case, the lack of Ca++, which inhibited the release of FSH, would consequently inhibit its synthesis. (Endocrinology86: 761, 1970)
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Jutisz et al. (1970) studied this question.