Demonstrates a species or cell-type specific requirement for protein synthesis in the initial stages of interferon induction.
Cell-type differences in interferon induction pathways in animal models; leaves open human translational relevance and mechanistic uniformity.
The initial stages of interferon induction in mouse L cells do not require protein synthesis; all steps in the induction process up to and including the transcription of interferon mRNA occurred in the presence of inhibitors of protein synthesis. In contrast, interferon induction in primary chick embryo cells aged in vitro does require a reaction that depends upon protein synthesis, unique in that it is not required for virus replication or the action of interferon.
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Svitlik et al. (1985) studied this question.
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