Abortive Infection of L Cells by Fowl Plague Virus: Comparison of RNA and Protein Synthesis in Infected Chick and L Cells

SUMMARY When L cells were infected with fowl plague virus, virus haemagglutinin, neuraminidase and complement-fixing antigen, but no infectious virus, were produced. Comparison with infection of chick cells showed that, in both cases, there was an early period of sensitivity to actinomycin and that infection caused depression of host-cell protein synthesis. There was no difference in the distribution of newly synthesized virus RNA between the nucleus and cytoplasm in both chick cells and L cells, and all the virus proteins synthesized in chick cells were also synthesized in L cells. However, the two proteins found in the nucleus did not appear to move out of the nuclei of L cells.