Key result
Plasma ganglioside patterns varied by disease, with GM3 increased in gastric cancer, GT1b decreased in HAM and ATL, and GD3, GM1, and GM3 decreased in ALL compared to normal controls.
Why the study?
Do plasma ganglioside patterns differ between patients with specific neoplastic or retroviral diseases and normal controls?
Population
Patients with neoplastic diseases including gastric cancer, adult T-cell leukemia, acute lymphocytic…
Comparison
Quantitation and qualitation of gangliosides in… vs Normal control plasmas
Design
Case-control
Authors
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Ganglioside pattern differences were associated with specific diseases; hypothesis-generating for biomarker development, requiring prospective validation before clinical use.
Case-Control
Do plasma ganglioside patterns differ between patients with specific neoplastic or retroviral diseases and normal controls?
Plasma ganglioside patterns show specific alterations in various neoplastic and retroviral diseases, suggesting potential diagnostic and therapeutic value.
Ayabe et al. (1989) conducted a case-control in Neoplastic diseases (gastric cancer, ATL, ALL) and HAM. Plasma ganglioside patterns vs. Normal control plasmas was evaluated on Ganglioside patterns (GM3, GT1b, GD3, GM1). Plasma ganglioside patterns varied by disease, with GM3 increased in gastric cancer, GT1b decreased in HAM and ATL, and GD3, GM1, and GM3 decreased in ALL compared to normal controls.
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