A ring expansion and a radical dehalogenation have been used as the key steps in a formal total synthesis of (−)-paroxetine. The substituted piperidine ring precursor of (−)-paroxetine was generated by means of a stereoselective ring expansion of prolinol. (© Wiley-VCH Verlag GmbH, 69451 Weinheim, Germany, 2002)
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Cossy et al. (2002) studied this question.