Key result
Ionized magnesium levels were significantly lower in patients with anxiety and depression compared to healthy volunteers (p=0.003) and correlated with oxidative stress parameters.
Why the study?
Ionized magnesium is the only active form of magnesium, and its concentration could serve as a potentially novel biomarker for anxiety and depression.
Does the serum concentration of ionized magnesium correlate with biomarkers of oxidative stress and inflammation in patients with anxiety and depression?
Cross-Sectional (n=93)
No
Does the serum concentration of ionized magnesium correlate with biomarkers of oxidative stress and inflammation in patients with anxiety and depression?
Ionized magnesium levels and their correlation with oxidative stress parameters may serve as potential biomarkers for anxiety and depression.
Answers are grounded in this paper and cite their sources.
Ionized Mg may link to oxidative stress in anxiety/depression; leaves open biomarker validation before any clinical role.
Background: Magnesium (Mg) is the second most abundant intracellular cation. Ionized Mg is the only active form of Mg. The concentration of ionized Mg could be a potentially novel biomarker for anxiety and depression. Aim: The aim of this study was to assess the serum concentration of ionized Mg and its correlation with biomarkers of oxidative stress and inflammation in patients with anxiety and depression. Methods: In this study included 93 respondents were divided into 3 groups: C (control group-18 respondents); A (patients with anxiety disorder, dissociative/conversion disorders and somatoform disorders-36 patients); D (patients with depression-39 patients). Clinical diagnosis was based on ICD-10 criteria. Blood samples were used for standard laboratory analysis, ionized Mg analysis, oxidative stress, and inflammatory parameters. Results: Statistical significance was recorded between healthy volunteers and patients (anxiety/depression) in ionized Mg values. In anxious patients, malondialdehyde (MDA) had a positive correlation between the parameters of oxidative stress with ionized Mg. In depressive patients, MDA had a positive correlation, and glutathione peroxidase 1 (GPX1) a negative correlation with the concentration of ionized Mg. Conclusion: Ionized Mg and its correlation with parameters of oxidative stress could be potential biomarkers in anxious and depressive patients.
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Opanković et al. (2022) conducted a cross-sectional in Anxiety and Depression (n=93). Ionized magnesium concentration vs. Healthy volunteers was evaluated on Serum concentration of ionized magnesium (p=0.003). Ionized magnesium levels were significantly lower in patients with anxiety and depression compared to healthy volunteers (p=0.003) and correlated with oxidative stress parameters.
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