No metal required: A protocol for the enantioselective organocatalytic chlorination of cyclic and acyclic β-keto esters and cyclic β-diketones has been developed which is also effective for the asymmetric bromination of β-keto esters. The methodology employs an inexpensive organocatalyst (e.g. benzoylquinidine) and polyhalogenated quinolinones as the source of the halogen (see scheme).
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Bartoli et al. (2005) studied this question.
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