Key result
This review examines current viral vectors for small RNA delivery, comparing their advantages and drawbacks to aid in selecting the optimal vector.
Why the study?
While non-viral vectors have been extensively explored for delivering small RNAs, viral vectors offering superior specificity and delivery efficiency remain less studied.
This review provides a comprehensive comparison of viral vectors for small RNA delivery to aid in selecting optimal vectors for therapeutic applications.
May expand RNAi options for cancer and infections; leaves open optimal vector selection for clinical use.
RNA interference regulates gene expression by selectively silencing target genes through the introduction of small RNA molecules, such as microRNA, small interfering RNA and short hairpin RNA. These molecules offer significant therapeutic potential for diverse human ailments like cancer, viral infections and neurodegenerative disorders. Whilst non-viral vectors like nanoparticles have been extensively explored for delivering these RNAs, viral vectors, with superior specificity and delivery efficiency, remain less studied. This review examines current viral vectors for small RNA delivery, focusing on design strategies and characteristics. It compares the advantages and drawbacks of each vector, aiding readers in selecting the optimal one for small RNA delivery.
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Yusoff et al. (2025) reported a review. Viral vectors for small RNA delivery was evaluated. This review examines current viral vectors for small RNA delivery, comparing their advantages and drawbacks to aid in selecting the optimal vector.
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