Practical Process Development of AMCA from Recyclable Source MFB

재활용이 가능한 자원인 MFB를 출발 물질로 하여 AMCA의 합성을 진행하였으며, AMBA로부터 AMCA로의 최적의 상업화 합성 조건을 찾고자 촉매, 수소 압력, 반응 온도, 반응 시간 같은 공정 변수를 조사하였다. 최적의 조건은 촉매는 [5% Pd/C : 5% Pt/C : 5% Rh/C (1 : 1 : 1)]의 복합 촉매를 반응 시간은 8 h, 반응 온도는 130∘C , 압력은 30 bar일 때(수율 90%, 순도 99.9%)임을 확인하였다. A facile synthesis of 4-(aminomethyl)cyclohexanecarboxylic acid (AMCA) from recyclable methyl 4-formylbenzoate (MFB) was described. In particular, we investigated the best process variables such as catalyst, hydrogen pressure, reaction temperature, and reaction time for AMCA conversion from AMBA through hydrogenation reaction. The best conditions were found to be as follows: the catalyst as [5% Pd/C, 5% Pt/C, 5% Rh/C (1 : 1 : 1)] which is a composite catalyst, the pressure as 30 bar, the reaction time as 8 hours and the reaction temperature at 130∘C . Under the condition, a 90% yield (purity 99.9%) for the mass production of AMCA was achieved.