Key result
Adiponectin suppresses atherogenesis by inhibiting monocyte adherence and reducing modified lipoprotein accumulation, and hypoadiponectinemia may contribute to thrombus formation.
Adiponectin plays a protective role against atherosclerosis and thrombosis by modulating endothelial function and monocyte activity.
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Adiponectin modulation merits exploration in atherothrombosis; leaves open clinical adoption pending interventional trials.
Obesity is a major risk factor for morbidity and mortality from cardiovascular causes. Adiponectin has been identified recently as one of the adipocytokines with important metabolic effects. It can suppress atherogenesis by inhibiting the adherence of monocytes, reducing their phagocytic activity, and suppressing the accumulation of modified lipoproteins in the vascular wall. In addition, as adiponectin decrease endothelial damage and stimulates production of NO from vascular endothelial cells, hypoadiponectinemia may be partially contribute to thrombus formation.
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Ekmekçi et al. (2006) conducted a review in Atherosclerosis and Thrombosis. Adiponectin was evaluated. Adiponectin suppresses atherogenesis by inhibiting monocyte adherence and reducing modified lipoprotein accumulation, and hypoadiponectinemia may contribute to thrombus formation.
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