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An unexpected amino acid metabolism is used by a subspecies of the soil bacterium Streptomyces violaceoniger to produce the antifungal antibiotic pyridazomycin 1-C1. Feeding studies with isotopically labeled precursors indicate that 1 is constructed from ornithine, glycine, and probably oxaloacetate.
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Bockholt et al. (1994) studied this question.
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