Key result
Higher placental mitochondrial DNA copy number (≥120.5) was associated with a 2.38-fold increased odds of placental abruption compared to lower copy numbers.
Why the study?
Is higher placental mitochondrial DNA copy number associated with increased odds of placental abruption?
Case-Control (n=205)
Single-blind
Yes
Is higher placental mitochondrial DNA copy number associated with increased odds of placental abruption?
Odds Ratio: 2.38 (95% CI 1.11–5.08)
Higher placental mitochondrial DNA copy number, a marker of mitochondrial dysfunction, is associated with increased odds of placental abruption.
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Hypothesis-generating for mitochondrial biomarkers in abruption; should not yet change clinical practice.
Qiu et al. (2015) conducted a case-control in Placental abruption (n=205). Higher placental mitochondrial DNA (mtDNA) copy number (≥120.5) vs. Lower placental mtDNA copy number (<120.5) was evaluated on Placental abruption (adjusted OR 2.38, 95% CI 1.11-5.08). Higher placental mitochondrial DNA copy number (≥120.5) was associated with a 2.38-fold increased odds of placental abruption compared to lower copy numbers.
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