Key result
Composite electrode tips with steroid-releasing collars eliminated the 2-week threshold peaking seen with control leads (P<0.005 for controls) and maintained stable, low thresholds for up to 6 months.
Why the study?
Does a composite electrode tip with a dexamethasone-releasing collar improve voltage thresholds and impedances in a sheep model?
Population
Sheep model with unipolar ventricular leads implanted transvenously in the right ventricular apex
Comparison
Composite electrode tip combined with a… vs Conventional Telectronics Laserpor and Laserdish…
Design
Preclinical
Follow-up
up to 6 months
Authors
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Preclinical stability with steroid collars warrants human lead trials; leaves open clinical translation and long-term safety.
Does a composite electrode tip with a dexamethasone-releasing collar improve voltage thresholds and impedances in a sheep model?
p-value: p=<0.005
Steroid-eluting collars on pacing leads prevent acute threshold peaking and maintain low chronic pacing thresholds in a preclinical model.
Brewer et al. (1988) studied this question. Composite electrode tip with polymeric collar containing dexamethasone sodium phosphate (DSP) vs. Conventional Telectronics Laserpor (LP) or Laserdish (LD) electrodes was evaluated on Voltage thresholds, pacing and sensing impedances (p=<0.005). Composite electrode tips with steroid-releasing collars eliminated the 2-week threshold peaking seen with control leads (P<0.005 for controls) and maintained stable, low thresholds for up to 6 months.
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