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October 1, 2000HeartOpen Access

Right ventricular enlargement assessed by three-dimensional echocardiography significantly correlates with QRS duration (r=0.61, p<0.01), indicating mechanoelectrical interaction in repaired tetralogy of Fallot.

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Population

40 patients with repaired tetralogy of Fallot, mean age 14.3 years, followed at a tertiary cardiac centre in…

Design

Cross-sectional

Follow-up

9.5 years (mean follow-up since surgical repair)

Key result

Right ventricular enlargement assessed by three-dimensional echocardiography significantly correlates with QRS duration (r=0.61, p<0.01), indicating mechanoelectrical interaction in repaired tetralogy of Fallot.

Authors

MRMohamed Y. Abd El Rahman

Discussion

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Overview

Should not yet alter surveillance in repaired tetralogy of Fallot; leaves open causal links to arrhythmia risk.

Study Design

Type

Cross-Sectional (n=40)

Multicenter

No

Structured PICO

P
Population
40 asymptomatic patients with repaired tetralogy of Fallot, aged 3 to 44 years, were evaluated to assess the relationship between right ventricular enlargement, QRS duration, and right ventricular function.
O
Outcome
Correlation between right ventricular end-diastolic volume (assessed by three-dimensional echocardiography) and QRS duration on surface ECGsurrogate

Main Result

Effect estimate: r = 0.61

p-value: p=<0.01

In patients with repaired tetralogy of Fallot, right ventricular enlargement correlates with QRS prolongation, and severe pulmonary regurgitation negatively impacts right ventricular global function.

Limitations

  • Selection bias as only patients with adequate transthoracic echocardiographic windows were examined.
  • Three-dimensional echocardiography and magnetic resonance imaging are time-consuming and require expensive equipment.
  • Doppler assessment of the severity of pulmonary regurgitation may not be the ideal method for quantification compared to magnetic resonance flow studies.
  • Selection bias due to inclusion of only patients with adequate transthoracic echocardiographic windows
  • Three-dimensional echocardiography and MRI are time-consuming and require expensive equipment
  • Doppler assessment of pulmonary regurgitation severity may not be the ideal method compared to magnetic resonance flow studies

Cite This Study

Mohamed Y. Abd El Rahman (2000) conducted a cross-sectional in Repaired tetralogy of Fallot with pulmonary regurgitation (n=40). Severe pulmonary regurgitation and right ventricular enlargement vs. Mild to moderate pulmonary regurgitation was evaluated on Correlation between QRS duration and right ventricular end diastolic volume (r = 0.61, p=<0.01). Right ventricular enlargement assessed by three-dimensional echocardiography significantly correlates with QRS duration (r=0.61, p<0.01), indicating mechanoelectrical interaction in repaired tetralogy of Fallot.

synapsesocial.com/papers/6a96754d62b3be453f898042https://doi.org/10.1136/heart.84.4.416
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