Key result
A 73-year-old man with Streptococcus sanguinis lead endocarditis experienced an asymptomatic complete ventricular lead rupture while being medically managed with prolonged antibiotic therapy.
Why the study?
CIED-related infections carry severe morbidity and mortality, but few cases have documented both lead endocarditis and lead rupture simultaneously.
Case Report (n=1)
This case highlights that medically managed CIED lead endocarditis may lead to structural lead failure, reinforcing that complete hardware removal remains the first-line therapy.
Answers are grounded in this paper and cite their sources.
Alerts clinicians to concurrent CIED lead endocarditis and rupture; extends sparse case literature but leaves optimal management open.
Background Cardiac implantable electronic device (CIED)-related infections are associated with severe morbidity and mortality. Few cases have previously documented both lead endocarditis and lead rupture simultaneously. Case summary We describe the case of a 73-year-old man with a dual-chamber pacemaker presenting with subacute endocarditis and recurrent cholangitis. A few months prior, the patient was diagnosed with localized colon cancer and Streptococcus sanguinis lead endocarditis based on nuclear imaging. He was given prolonged antibiotic therapy and lead explantation was to be performed after sigmoidectomy. During the following weeks, his condition worsened and he was readmitted for biliary sepsis. A chest X-ray revealed, incidentally, a complete ventricular lead rupture. Pacemaker electrogram showed ventricular undersensing, loss of ventricular capture, and high impedance. As his health declined, removal of the pacemaker was deemed unreasonable and the patient died of biliary sepsis in the next few weeks. Discussion We describe the case of an asymptomatic intracardiac lead fracture in the setting of colon cancer and a medically managed Streptococcus lead infection. As this complication occurred during lead infection, bacterial damage may have weakened the lead over time. As illustrated by the patient’s outcomes, long-term antibiotic therapy should only be used in cases unsuitable for device removal. Complete hardware removal remains the first-line therapy in patients with CIED-related infections.
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Lanzacco et al. (2022) conducted a case report in Subacute endocarditis and pacemaker lead rupture (n=1). Prolonged antibiotic therapy was evaluated. A 73-year-old man with Streptococcus sanguinis lead endocarditis experienced an asymptomatic complete ventricular lead rupture while being medically managed with prolonged antibiotic therapy.
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