Key result
Dihydroquercetin at a concentration of 100 µg/ml reduced Coxsackievirus B4 viral titers by 2 lg EID50/0.2 ml in vitro compared to the virus control.
Why the study?
Does dihydroquercetin reduce viral replication in Coxsackievirus B4 in vitro?
Does dihydroquercetin reduce viral replication in Coxsackievirus B4 in vitro?
Dihydroquercetin demonstrates in vitro antiviral activity against Coxsackievirus B4, particularly during early stages of viral reproduction.
Answers are grounded in this paper and cite their sources.
Supports preclinical antiviral research; leaves open clinical translation pending in vivo studies.
A study of the antiviral activity of antioxidants against viral infections is believed to be essential for creating complex antiviral agents. Dihydroquercetin is considered as the most active antioxidant extracted from larix gmelinii. In this work, we present results of experiments of the antiviral properties of dihydroquercetin against a member of the family picornaviridae – Coxsackievirus B4 in vitro. We have estimated that dihydroquercetin reduces viral titers at 100 µg/ml concentration as compared with control of virus. We have shown using the plaque assay that cpe of virus is reduced in the presence of dihydroquercetin at 100 µg/ml. Study of the phase of viral life cycle, in which dihydroquercetin acted, demonstrated that the highest efficacy of the antiviral therapy was reached at early stages of virus reproduction (1-3 hours post infection). These results show that dihydroquercetin has antiviral property against Coxsackievirus B4. This drug and other antioxidants can be tested as inhibitors of viral replication.
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Galochkina et al. (2016) studied Coxsackievirus B4 infection. Dihydroquercetin vs. Virus control was evaluated on Viral titer (lg EID50/0.2 ml) (reduction of 2 lg EID50/0.2 ml). Dihydroquercetin at a concentration of 100 µg/ml reduced Coxsackievirus B4 viral titers by 2 lg EID50/0.2 ml in vitro compared to the virus control.
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