Multicomponent Synthesis of Cyclic Frameworks on Knoevenagel-Initiated Domino Reactions

Major aspects of multicomponent synthesis of cyclic frameworks are reviewed with special focus on Knoevenagel-based domino reactions. Particularly, the Knoevenagel-Cycloaddition and the Knoevenagel-Michael cascades are the majority of reaction types which contribute to the building of complicated cyclic molecular scaffolds. Although samples of the other Knoevenagel-induced reactions are not abundant, their creativity in production of novel cyclic structures should not be neglected. The presented reports herein are sufficient enough to confirm that Knoevenagel-induced domino reactions have been one of the most powerful and productive tools for the construction of novel and complicated frameworks.