Answers are grounded in this paper and cite their sources.
Animal experiment evaluates pituitary LH response to LH-RH in immature cyproterone-treated male rats, highlighting antiandrogen effects on the hypothalamo-pituitary axis.
Treatment of intact males of many species with cyproterone mimics the effects of surgical castration, but whereas castration suppresses gonadal androgen secretion, cyproterone acts centrally and peripherally by inhibiting the action of testosterone at androgen receptor sites (Davidson & Bloch, 1969; Neumann et al., 1969). Cyproterone is considered to be a 'pure' antiandrogen since it has no progestagenic effect, and can be used to stimulate the hypothalamo-pituitary axis (Bloch & Davidson, 1967; Viguier-Martinez & Pelletier, 1972). The present study was undertaken to examine if the pituitary response of male rats to LH-RH was modified by cyproterone, and the response was compared to that observed in intact and castrated animals.
No takes yet. Share an insight, caveat, or question.
M.C. Viguier-Martinez (1976) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: