Evidence that hormones affect the abnormal as well as the normal metabolism of the cell necessitates a comprehensive review of the relationship of hormones to neoplastic disease. Drs. Twombly and Pack have enlisted the aid of eighteen experts in the preparation of this monograph. Material on which this monograph is based first appeared inSurgery, July and August 1944. These articles have since been thoroughly revised and brought up to date as of August 1946. The book is divided into three parts: The first part deals with experimental tumors induced by steroid hormones; particular attention is paid to tumors developing in the genital tract. Discussion of evidence regarding effects of continued use of female sex hormones on subsequent development of neoplastic disease in human beings is of interest. The conclusion is reached that although under special conditions in animals it is possible to increase the incidence of such tumors it
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A 1948 study studied this question.