Effect of extracts from iris milk-white and celery on body composition and glucose levels in leptin-resistant mice

Introduction. The practical approach to treating diabetes mellitus often overlooks the management of obesity, focusing primarily on glycemic control. Consequently, there is a growing need to explore pharmacological strategies for obesity treatment within the so-called diabetic syndrome. Certain plant species contain a wide range of biologically active compounds that may have beneficial effects on metabolic processes in the body. Aim. To investigate the effects of a complex of polyphenolic compounds from Iris lactea herb and polysaccharides and pectins from Apium graveolens rhizomes on body weight and fat content in leptin-resistant diabetic mice. Materials and methods. The experiment employed bioimpedance analysis and blood biochemical analysis to measure glucose levels. Results and discussion. It was found that the studied phytosubstances led to a reduction in body weight and adipose tissue proportion in the animals compared to the control group. Additionally, the group treated with Iris lactea extracts showed a decrease in blood glucose levels. Conclusion. The obtained data confirm the potential use of Iris lactea and Apium graveolens extracts as sources of bioactive compounds for developing obesity treatment agents.