Use of Fluorescent Dyes in Endoscopy and Diagnostic Investigation

BACKGROUND: The advancement of innovative endoscopic technology in terms of improving the visualization of the mucosa has been of significant benefit. SUMMARY: Advancements in image resolution, software processing, and optical filter technology have resulted in several techniques complemental to traditional white light endoscopy. These new techniques provide a real-time optical diagnosis as well as virtual histology of detected lesions. Optical molecular imaging permits a functional assessment within cells. KEY MESSAGE: Optical molecular imaging provides an understanding of cellular processes and permits validation of the specificity of fluorescent tracers and the possibility of quantifying the signal.