Bilirubin did not appear in the blood or thoracic duct lymph when the intrabiliary pressure was lower than the secretory pressure of the liver. Obstruction of the common duct by raising the intrabiliary pressure above the secretory pressure of the liver resulted in bilirubinemia of approximately constant level, and in the appearance of bilirubin in the lymph in concentrations which increased as the intrabiliary pressure was increased.
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Shafiroff et al. (1939) studied this question.
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