Safety of Psychotropic Medications During Pregnancy: An update on Antipsychotics, Anxiolytics & Sedative Hypnotics, Stimulants, and Medications for Treatment of Substance Use Disorders.

Q: What does this research mean for the field?

The management of psychiatric conditions during pregnancy requires weighing the updated safety and efficacy data of psychotropic medications against the risks of leaving these disorders untreated. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

Edwin Raffi; Ruta Nonacs; Lee S Cohen

doi:10.1016/j.clp.2026.05.011

September 1, 2026

Safety of Psychotropic Medications During Pregnancy: An update on Antipsychotics, Anxiolytics & Sedative Hypnotics, Stimulants, and Medications for Treatment of Substance Use Disorders.

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Key Points

To review updated evidence on the safety and efficacy of psychotropic medications during pregnancy and assess the clinical consequences of leaving psychiatric disorders untreated.
Literature synthesis assessing evidence on antipsychotics, anxiolytics, sedative-hypnotics, stimulants, and substance use disorder therapies.
Qualitative evaluation comparing fetal and maternal drug exposure risks against the morbidity of untreated maternal mental illness.
Updated safety and efficacy profiles are detailed across multiple psychotropic medication classes to guide perinatal prescribing decisions.
Untreated psychiatric illness and substance use disorders carry substantial maternal and fetal risks that must be weighed against medication adverse effects.

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Implication

Review evaluates the safety of psychotropic drugs during pregnancy, highlighting the clinical risks of untreated psychiatric conditions.

Abstract

The objective of this article is to discuss the most updated data on the safety and efficacy of some psychotropic medications during pregnancy, specifically antipsychotic medications, anxiolytic and sedative hypnotics, stimulant medications, and medications for treatment of substance use disorders (SUDs). The common disorders and the risks of not receiving treatment for certain psychiatric conditions, including SUDs, are also discussed.

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Raffi et al. (2026) studied this question.

synapsesocial.com/papers/6a9691257a497a6ca291f21c https://doi.org/10.1016/j.clp.2026.05.011

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Safety of Psychotropic Medications During Pregnancy: An update on Antipsychotics, Anxiolytics & Sedative Hypnotics, Stimulants, and Medications for Treatment of Substance Use Disorders.

Key Points

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Implication

Abstract

Discussion

Cite This Study

Safety of Psychotropic Medications During Pregnancy: An update on Antipsychotics, Anxiolytics & Sedative Hypnotics, Stimulants, and Medications for Treatment of Substance Use Disorders.

Key Points

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Implication

Abstract

Discussion

Cite This Study

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