Key result
The potency of adenovirus immune complexes in inducing dendritic cell maturation strongly correlated with the number of Toll-like receptor 9-agonist motifs in the adenovirus vector's genome.
The number of TLR9-agonist motifs in adenovirus genomes determines their ability to induce dendritic cell maturation via immune complexes, which has implications for HIV vaccine development.
Adenovirus serotype 5 (Ad5) vectors and specific neutralizing antibodies (NAbs) generate immune complexes (ICs) which are potent inducers of dendritic cell (DC) maturation. Here we show that ICs generated with rare Ad vector serotypes, such as Ad26 and Ad35, which are lead candidates in HIV vaccine development, are poor inducers of DC maturation and that their potency in inducing DC maturation strongly correlated with the number of Toll-like receptor 9 (TLR9)-agonist motifs present in the Ad vector's genome. In addition, we showed that antihexon but not antifiber antibodies are responsible for the induction of Ad IC-mediated DC maturation.
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Perreau et al. (2012) studied this question. Adenovirus immune complexes was evaluated on Dendritic cell maturation. The potency of adenovirus immune complexes in inducing dendritic cell maturation strongly correlated with the number of Toll-like receptor 9-agonist motifs in the adenovirus vector's genome.
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