July 2, 2009The Journal of Organic Chemistry

A Simple and Convenient Copper-Catalyzed Tandem Synthesis of Quinoline-2-carboxylates at Room Temperature

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HHHe HuangNational Taipei University of Technology HJHualiang JiangShanghai Institute of Materia Medica KCKaixian ChenGuangzhou University of Chinese Medicine

Abstract

We developed a simple and convenient copper-catalyzed method for the synthesis of quinoline-2-carboxylate derivatives through sequential intermolecular addition of alkynes onto imines and subsequent intramolecular ring closure by arylation. The efficiency of this system allowed the reactions to be carried out at room temperature.

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Huang et al. (2009) studied this question.

synapsesocial.com/papers/6a96981b6fa607f2afb2e155 https://doi.org/10.1021/jo901101v

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A Simple and Convenient Copper-Catalyzed Tandem Synthesis of Quinoline-2-carboxylates at Room Temperature

Abstract

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A Simple and Convenient Copper-Catalyzed Tandem Synthesis of Quinoline-2-carboxylates at Room Temperature

Abstract

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