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In aqueous solution, anthramycin methyl ether (AME), anhydroanthramycin (an imino form) and anthramycin are in equilibrium. It is found that anhydroanthramycin is electrochemically active. The AME hydrolysis reaction is studied by cyclic voltammetry. The kinetics of the DNA-drug reaction is followed by AdTSV and it is found that the slowness of the interaction is due to anthramycin changes which take place in solution independently of the DNA presence. DPP is used as a sensitive method for the quantitative determination of the drug and a detection limit of 70 nM is obtained.
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Teijeiro et al. (2000) studied this question.
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