What is the clinical evidence from this study?

Study design: Review. Population: Thrombosis / Atrial fibrillation. Intervention: Direct oral anticoagulants (DOACs).

March 10, 2016Journal of Intensive CareOpen Access

Profiles of direct oral anticoagulants and clinical usage—dosage and dose regimen differences

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Key result

Calculated relative potencies of direct oral anticoagulants differ significantly, with apixaban showing higher potency than edoxaban and nearly twice that of rivaroxaban.

Design

Review

Authors

MIMasahiro IekoSapporo Medical University SNSumiyoshi NaitohHealth Sciences University of Hokkaido MYMika YoshidaHokkaido University Hospital

Discussion

Member takes

Implication

DOAC potency calculations should not yet change practice; hypothesis-generating for outcome validation studies.

Structured PICO

Intervention

Direct oral anticoagulants (dabigatran, rivaroxaban, apixaban, edoxaban)

Outcome

Relative potency based on molecular weight, bioavailability, protein-binding rate, inhibitory constant, and dosagesurrogate

Pharmacological profiling suggests that twice-daily apixaban provides persistent anticoagulation similar to warfarin, whereas once-daily rivaroxaban provides intermittent anticoagulation.

Limitations

Data used for calculations were obtained under varying circumstances during drug development phases.
Clinical outcomes cannot be directly compared at this time and should not be considered accurate.
Clinical outcomes cannot be directly compared at this time
Data available were obtained under varying circumstances during drug development phases

Cite This Study

Ieko et al. (2016) conducted a review in Thrombosis / Atrial fibrillation. Direct oral anticoagulants (DOACs) was evaluated. Calculated relative potencies of direct oral anticoagulants differ significantly, with apixaban showing higher potency than edoxaban and nearly twice that of rivaroxaban.

synapsesocial.com/papers/6a9699927c15eaca025783cc https://doi.org/10.1186/s40560-016-0144-5

View Full Paper

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Profiles of direct oral anticoagulants and clinical usage—dosage and dose regimen differences

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Profiles of direct oral anticoagulants and clinical usage—dosage and dose regimen differences

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider