This thematic review discusses the pharmacodynamics and pharmacokinetics of apixaban and rivaroxaban, highlighting the use of the thrombin generation test to assess their effectiveness and safety.
This review summarizes the pharmacodynamics and pharmacokinetics of apixaban and rivaroxaban, highlighting the use of the thrombin generation test to assess anticoagulant activity.
The thematic review presents modern solutions using oral anticoagulants with a focus on direct coagulation factor X inhibitors. It contains information about the pharmacodynamics and pharmacokinetics of apixaban and rivaroxaban against the background of different drug intake regimens - twice and once per day. There are shown studies of concentration dynamics and the corresponding functional response, measured using the integral method - the thrombin generation test, which is widely used in scientific research to describe hemostatic processes based on an objective quantitative assessment of the thrombin formation - a key coagulation cascade serine protease. The logical relationship between the pharmacodynamics of anticoagulant action and the clinical presentation of the effectiveness and safety of drugs is traced. The review provides links to actual literature and current clinical guidelines.
Т. В. Вавилова (2019) conducted a review in Anticoagulant therapy. Direct factor Xa inhibitors (apixaban and rivaroxaban) was evaluated. This thematic review discusses the pharmacodynamics and pharmacokinetics of apixaban and rivaroxaban, highlighting the use of the thrombin generation test to assess their effectiveness and safety.