PREVIOUS STUDIES on the effect of administered thyroid hormone on the thyroid gland have revealed the fundamental fact that when an animal receives an excess of exogenous thyroid substance, its own thyroid gland is put in a resting state, characterized by a decrease i n total size, a diminution in height of thyroid epithelium and an accumulation of colloid (Herring, 1917; Cameron and Carmichael, 1920). Loeb (1929) further demonstrated that the compensatory hypertrophy of the thyroid gland resulting from partial ablation of the thyroid gland can be entirely prevented by administering thyroid hormone. Following the discovery of the existence of a thyrotropic hormone in the anterior pituitary gland, Aron (1930), Loeb, Bassett, and Friedman (1930) and Loeser (1934), showed that in guinea pigs the simultaneous administration of thyroid hormone along with an active extract of the anterior pituitary prevented in part the usual hypertrophy of the thyroid gland which follows the injection of thy-rotropic hormone.
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Cortell et al. (1944) studied this question.