Key result
Severe aortic valve stenosis was independently associated with a higher frequency of fragmented QRS compared to matched controls (46% vs 18%; OR 3.69; 95% CI 1.81-7.55; p<0.001).
Why the study?
Is severe aortic valve stenosis associated with an increased frequency of fragmented QRS compared to matched controls?
Case-Control (n=170)
Is severe aortic valve stenosis associated with an increased frequency of fragmented QRS compared to matched controls?
Severe aortic valve stenosis is independently associated with a higher frequency of fragmented QRS, suggesting a potential non-invasive marker for myocardial fibrosis in this population.
OBJECTIVE: To investigate the presence of myocardial fibrosis determined by fragmented QRS in patients with severe aortic valve stenosis. SUBJECTS AND METHODS: Eighty-seven consecutive patients with severe aortic valve stenosis and 83 age- and gender-matched control subjects were enrolled into this study. Severe aortic valve stenosis was defined as an aortic valve area <1 cm(2), a Vmax >4 m/s, or a mean gradient ≥40 mm Hg. Fragmented QRS was assessed using a 12-lead electrocardiogram. RESULTS: Fragmented QRS was detected in 40 (46%) patients in the aortic valve stenosis group and in 15 (18%) control subjects (p < 0.001). In multivariate binary logistic regression analysis, the presence of aortic valve stenosis was the only independent factor associated with fragmented QRS (OR = 3.69; 95% CI 1.81-7.55, p < 0.001). CONCLUSION: A higher frequency of fragmented QRS was detected in patients with severe aortic valve stenosis compared to controls.
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Ağaç et al. (2013) conducted a case-control in Severe aortic valve stenosis (n=170). Severe aortic valve stenosis vs. Age- and gender-matched control subjects was evaluated on Presence of fragmented QRS on 12-lead electrocardiogram (OR 3.69, 95% CI 1.81-7.55, p=< 0.001). Severe aortic valve stenosis was independently associated with a higher frequency of fragmented QRS compared to matched controls (46% vs 18%; OR 3.69; 95% CI 1.81-7.55; p<0.001).
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