During a six-month period (Dec 15, 1972, to June 15, 1973), hepatitis developed in five employees of a large, hospital-based clinical laboratory. Three employees had transient hepatitis B surface antigen (HB s Ag), one had antibody to surface antigen (anti-HB s ), and one had neither. In the two years preceding this outbreak, only one laboratory employee had had overt hepatitis. Risk-factor analysis for ill employees and a control group of HB s Ag- and anti-HB s -negative laboratory employees matched for age, length of employment, and amount of exposure to blood specimens showed that only a history of sustaining cuts while handling laboratory requisitions was statisticallysignificant ( P Recognition of the possible cause of the outbreak and adoption of problem-oriented preventive measures have been associated with no further clinical cases of hepatitis in the past year. ( JAMA 230:854-857, 1974)
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Charles P. Pattison (1974) studied this question.