Key result
A 20-point increase in subjective well-being scores was associated with higher odds of compliance with antipsychotic treatment (OR 1.363) in outpatients with schizophrenia.
Why the study?
Does subjective well-being improve compliance with antipsychotic treatment in outpatients with schizophrenia?
Observational (n=2,960)
Yes
Does subjective well-being improve compliance with antipsychotic treatment in outpatients with schizophrenia?
Compliance with antipsychotic medication in schizophrenia is strongly associated with subjective well-being, clinical symptoms, and side effects.
Answers are grounded in this paper and cite their sources.
Does not support changing practice; leaves open whether targeting well-being improves antipsychotic compliance in schizophrenia.
OBJECTIVE: Subjective well-being is considered important for compliance with antipsychotic treatment. The objective of this post hoc analysis of data from German patients in the Schizophrenia Outpatient Health Outcomes study was to investigate subjective well-being and compliance, with consideration of clinical symptoms and side effects, in outpatients diagnosed with schizophrenia. METHOD: In a multicenter observational study of 2960 patients with DSM-IV-defined schizophrenia recruited between January and December 2001, subjective well-being was measured during 12 months with the Subjective Well-Being Under Neuroleptic Treatment Scale, short version (SWN-K). Compliance was self- and physician-rated. The association of compliance with clinical parameters was assessed by logistic regression. RESULTS: Factor analysis resulted in 3 factors: SWN-K (r2 = 0.867), clinical symptoms (r2 = 0.744), and side effects (r2 = 0.420). The odds for being compliant were 1.363 times higher if the SWN-K score increased by 20 points. Changes in positive symptoms (OR = 0.773) and changes in extrapyramidal symptoms (OR = 0.830) were found to be associated with compliance. CONCLUSION: Compliance with antipsychotic medication was strongly associated with subjective well-being; further factors were clinical symptoms and side effects.
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Karow et al. (2007) conducted an observational in Schizophrenia (n=2,960). Subjective well-being (SWN-K score) was evaluated on Compliance with antipsychotic treatment (OR 1.363). A 20-point increase in subjective well-being scores was associated with higher odds of compliance with antipsychotic treatment (OR 1.363) in outpatients with schizophrenia.
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