Key result
Anticontractile influences of perivascular tissue were attenuated in coronary arteries from a type 2 diabetes rat model but unaffected in a type 1 diabetes model.
Altered signaling between cardiomyocyte-rich perivascular tissue and coronary arteries may contribute to cardiovascular complications in type 2 diabetes mellitus.
Distinguishes type 2 from type 1 diabetes effects on coronary perivascular function in rats; leaves open relevance to human disease.
AIM: We tested the hypothesis that crosstalk between cardiomyocyte-rich perivascular tissue (PVT) and coronary arteries is altered in diabetes. METHODS: We studied the vasoactive effects of PVT in arteries from the Zucker Diabetic Fatty (ZDF) rat model of type 2 diabetes, streptozotocin (STZ)-treated Wistar rats with type 1 diabetes, and corresponding - heterozygous Zucker Lean (ZL) or vehicle-treated Wistar - control rats. Vasocontractile and vasorelaxant functions of coronary septal arteries with and without PVT were investigated using wire myography. RESULTS: ] - was reduced in arteries from ZDF compared to ZL rats. PVT inhibited serotonin-, U46619- and depolarization-induced vasoconstriction in arteries from ZL rats, but this anticontractile influence of PVT was attenuated in arteries from ZDF rats. Methacholine-induced vasorelaxation was smaller in arteries from ZDF than ZL rats both with and without PVT, and the antirelaxant influence of PVT was comparable between arteries from ZDF and ZL rats. We observed no differences in vasoconstriction, vasorelaxation or PVT-dependent vasoactive effects between arteries from STZ- and vehicle-treated Wistar rats. CONCLUSION: Anticontractile influences of PVT are attenuated in coronary arteries from ZDF rats but unaffected in arteries from STZ-treated rats. Signs of endothelial dysfunction are evident in coronary septal arteries - with and without PVT - from ZDF rats but not STZ-treated rats. We propose that altered signalling between cardiomyocyte-rich PVT and coronary arteries can contribute to cardiovascular complications in type 2 diabetes mellitus.
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Bonde et al. (2016) studied Diabetes mellitus. Diabetes mellitus (ZDF and STZ-treated rat models) vs. Zucker Lean or vehicle-treated Wistar control rats was evaluated on Vasocontractile and vasorelaxant functions of coronary septal arteries. Anticontractile influences of perivascular tissue were attenuated in coronary arteries from a type 2 diabetes rat model but unaffected in a type 1 diabetes model.
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