The maximum activity of the key glycolytic enzymes, hexokinase and 6-phosphofructokinase, was measured in tissues of control and cold-acclimated rats. The only significant change in activity was seen in brown adipose tissue where the activity of these enzymes was increased 2-fold. This increase in glycolytic capacity along with the hypertrophy of BAT observed in cold acclimation suggests that this tissue could play an important role in glucose utilisation by the rat.
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Cooney et al. (1982) studied this question.
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