Key result
Resistance to activated protein C (APC-R) was the most common defect underlying juvenile deep vein thrombosis in Indians, present in 39.2% of patients.
Why the study?
What is the prevalence of hereditary antithrombotic protein defects in young Indian patients with deep vein thrombosis?
Case-Control (n=115)
What is the prevalence of hereditary antithrombotic protein defects in young Indian patients with deep vein thrombosis?
Activated protein C resistance (APC-R) is the most common hereditary prothrombotic defect underlying juvenile deep vein thrombosis in the Indian population.
APC-R may inform initial thrombophilia testing in young Indian DVT patients; extends ethnic prevalence data but remains hypothesis-generating.
The role of hereditary antithrombotic protein defects in juvenile deep vein thrombosis (DVT) was evaluated. Fifty six young patients (age <45 yr) with doppler-proven DVT were investigated for the presence of resistance to activated protein C (APC-R), lupus anticoagulant (LA), anticardiolipin antibodies and deficiencies of protein C, protein S, ATIII activities. Fifty nine normal healthy individuals served as controls. APC-R was observed to be the commonest defect underlying the Indian DVT as seen in 39.2% of patients followed by elevated ACA (5.3%), PAI (2.8%), presence of LA (2.8%) and reduced ATIII levels (2.8%). None of the subjects had protein C or S deficiency. APC-R was associated with ATIII deficiency in one case, and elevated ACA in two cases. In two subjects, APC-R was associated with elevated PAI levels. Patients with more than one prothrombotic factor had a higher prevalence of pulmonary thromboembolism, suggesting that the thrombogenic potential of APC-R is enhanced by the presence of coexisting hereditary or acquired prothrombotic defect.
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Saxena et al. (1999) conducted a case-control in Juvenile deep vein thrombosis (DVT) (n=115). Hereditary antithrombotic protein defects vs. Normal healthy individuals was evaluated on Presence of resistance to activated protein C (APC-R). Resistance to activated protein C (APC-R) was the most common defect underlying juvenile deep vein thrombosis in Indians, present in 39.2% of patients.
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