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Dropping anchor: Glycosylphosphatidylinositol (GPI) membrane-anchored proteins noncovalently associate with the plasma membrane and can have an impact on oncogenesis and some infectious diseases. The GPI anchor biosynthetic machinery and GPI-T, the transamidase that attaches them to proteins, are complicated, membrane-associated enzymes that are only beginning to be understood.
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Varma et al. (2010) studied this question.
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