What is the clinical evidence from this study?

Study design: Observational. Population: Takotsubo syndrome (n=26). Intervention: Takotsubo syndrome. Primary outcome: In-hospital mortality.

What does this research mean for the field?

In a Central/Eastern European cohort, Takotsubo syndrome predominantly affects elderly women following stress events and presents with significant systolic dysfunction, with in-hospital complication and mortality rates at the upper limit of previously published international values. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

What question did this study set out to answer?

To describe the clinical, echocardiographic, and biochemical characteristics of consecutive patients hospitalized with Takotsubo syndrome over a five-year period.

September 1, 2026Cardiology Research0 citationsOpen Access

Clinical and Echocardiographic Profiles of Patients Hospitalized With Takotsubo Syndrome

Takotsubo Syndrome: Clinical and Diagnostic Characteristics of 26 Consecutively Hospitalized Patients Over a Five-Year Period

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Why the study?

In-hospital complications and mortality in TTS remain clinically significant, but data from Central and Eastern European populations are underrepresented in international registries.

Population

26 consecutive patients hospitalized with TTS over a 5-year period

Design

Retrospective observational study (case series)

Key result

Among 26 hospitalized patients with Takotsubo syndrome, in-hospital mortality was 7.7%, complications occurred in 25% of survivors, and NT-proBNP inversely correlated with LVEF (ρ = -0.53).

Authors

MRMariya Radkova DRDanail Rangelov KKKiril Karamfilov

Discussion

Member takes

Overview

Small Takotsubo series supports known risks and NT-proBNP correlation; leaves open larger prospective validation.

Key Points

To describe the clinical, echocardiographic, and biochemical characteristics of consecutive patients hospitalized with Takotsubo syndrome over a five-year period.
Retrospective observational case series of N=26 consecutive hospitalized patients diagnosed according to the 2008 Mayo Clinic criteria over a five-year period.
Assessed demographic variables, physical and emotional triggers, echocardiographic findings, NT-proBNP levels, and in-hospital outcomes.
All patients presented with classic apical ballooning (100%) and an identifiable trigger (100%), with a mean initial LVEF of 41.8 ± 11.4% and an 88.5% female predominance (mean age 71.4 ± 12.0 years).
Serum NT-proBNP demonstrated a moderate inverse correlation with initial LVEF (Spearman ρ = −0.53).
In-hospital complications occurred in 25% of survivors, with an overall in-hospital mortality of 7.7% (2/26) and a mean length of stay of 12.1 ± 10.2 days.

Study Design

Type

Observational (n=26)

Multicenter

Structured PICO

Population

26 consecutive patients (88.5% women, mean age 71.4 years) hospitalized with Takotsubo syndrome over a 5-year period.

Outcome

Clinical, echocardiographic, and biochemical characteristics, including in-hospital complications and in-hospital mortality

This case series of Takotsubo syndrome patients highlights a 7.7% in-hospital mortality rate and 25% complication rate among survivors, emphasizing that the condition carries significant acute risks.

Limitations

Hypothesis-generating findings that require prospective multicenter validation

Cite This Study

Radkova et al. (2026) conducted an observational in Takotsubo syndrome (n=26). Takotsubo syndrome was evaluated on In-hospital mortality. Among 26 hospitalized patients with Takotsubo syndrome, in-hospital mortality was 7.7%, complications occurred in 25% of survivors, and NT-proBNP inversely correlated with LVEF (ρ = -0.53).

synapsesocial.com/papers/6a96b7f17a497a6ca291f4dc https://doi.org/10.14740/cr2249

View Full Paper

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September 1, 2026Cardiology Research0 citationsOpen Access

Clinical and Echocardiographic Profiles of Patients Hospitalized With Takotsubo Syndrome

Takotsubo Syndrome: Clinical and Diagnostic Characteristics of 26 Consecutively Hospitalized Patients Over a Five-Year Period

View Full Paper

Ask AI

Bookmark

Why the study?

In-hospital complications and mortality in TTS remain clinically significant, but data from Central and Eastern European populations are underrepresented in international registries.

Population

26 consecutive patients hospitalized with TTS over a 5-year period

Design

Retrospective observational study (case series)

Key result

Among 26 hospitalized patients with Takotsubo syndrome, in-hospital mortality was 7.7%, complications occurred in 25% of survivors, and NT-proBNP inversely correlated with LVEF (ρ = -0.53).

Authors

MRMariya Radkova DRDanail Rangelov KKKiril Karamfilov

Discussion

Member takes

Overview

Small Takotsubo series supports known risks and NT-proBNP correlation; leaves open larger prospective validation.

Key Points

To describe the clinical, echocardiographic, and biochemical characteristics of consecutive patients hospitalized with Takotsubo syndrome over a five-year period.
Retrospective observational case series of N=26 consecutive hospitalized patients diagnosed according to the 2008 Mayo Clinic criteria over a five-year period.
Assessed demographic variables, physical and emotional triggers, echocardiographic findings, NT-proBNP levels, and in-hospital outcomes.
All patients presented with classic apical ballooning (100%) and an identifiable trigger (100%), with a mean initial LVEF of 41.8 ± 11.4% and an 88.5% female predominance (mean age 71.4 ± 12.0 years).
Serum NT-proBNP demonstrated a moderate inverse correlation with initial LVEF (Spearman ρ = −0.53).
In-hospital complications occurred in 25% of survivors, with an overall in-hospital mortality of 7.7% (2/26) and a mean length of stay of 12.1 ± 10.2 days.

Study Design

Type

Observational (n=26)

Multicenter

Structured PICO

Population

26 consecutive patients (88.5% women, mean age 71.4 years) hospitalized with Takotsubo syndrome over a 5-year period.

Outcome

Clinical, echocardiographic, and biochemical characteristics, including in-hospital complications and in-hospital mortality

This case series of Takotsubo syndrome patients highlights a 7.7% in-hospital mortality rate and 25% complication rate among survivors, emphasizing that the condition carries significant acute risks.

Limitations

Hypothesis-generating findings that require prospective multicenter validation

Cite This Study

synapsesocial.com/papers/6a96b7f17a497a6ca291f4dc https://doi.org/10.14740/cr2249

View Full Paper

Ask AI

Bookmark