A novel water-soluble near-infrared glucose-conjugated porphyrin: synthesis, properties and its optical imaging effect

A simple novel near-infrared water-soluble glucose-conjugated porphyrin, 5,15-bis-[(trimethylsilyl)ethynyl]-10,20-bis[4-β-D-glucopyranosyl)phenyl]porphyrin, with good optical stability and high emission ability in near-infrared region, was synthesized. And Optical Imaging in vivo with this compound as probe was performed on liver tumor-bearing nude mice. The result shows that this glucose-conjugated porphyrin could display information in vivo more than 1 cm in depth, which implies its potential application as optical probe in cancer diagnosis.