Key result
Subarachnoid hemorrhage was associated with significantly reduced platelet function, including higher ADP thresholds for secondary aggregation and lower platelet adhesiveness compared to controls.
Why the study?
Does platelet function differ in patients with subarachnoid hemorrhage compared to controls?
Case-Control (n=135)
Does platelet function differ in patients with subarachnoid hemorrhage compared to controls?
Answers are grounded in this paper and cite their sources.
Patients with subarachnoid hemorrhage exhibit reduced platelet aggregation and adhesiveness compared to controls, suggesting altered platelet function may relate to the occurrence or consequence of the hemorrhage.
The hypothesis that abnormalities of platelet function may relate to the occurrence or recurrence of subarachnoid hemorrhage (SAH) has been examined. Seventy patients with SAH and 65 control individuals were studied. The adenosine diphosphate (ADP) threshold for secondary platelet aggregation was significantly higher in the SAH group than in the controls. In tests using 4.0 micrograms/ml ADP, the percent platelet aggregation (at 2 minutes) and the maximum rate of platelet aggregation (over 20 seconds) were significantly lower in the SAH patients. There was no difference in total platelet count between the two groups. Platelet adhesiveness was lower in the SAH patients when compared to controls. Circulating microaggregates did not differ between the two groups. The results indicate that reduced platelet function does relate to SAH and may either contribute to aneurysmal rupture in cases of SAH or be a consequence of it.
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Tsementzis et al. (1986) conducted a case-control in Subarachnoid hemorrhage (n=135). Subarachnoid hemorrhage vs. Control individuals was evaluated on Adenosine diphosphate (ADP) threshold for secondary platelet aggregation. Subarachnoid hemorrhage was associated with significantly reduced platelet function, including higher ADP thresholds for secondary aggregation and lower platelet adhesiveness compared to controls.
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