Single fetal death in twin gestations

Twin pregnancies are at higher risk for fetal mortality when compared with singleton pregnancies. Single fetal demise occurs in 3.7 – 6.8 % of all twin pregnancies and considerably increases the complication rate in the co-twin including fetal loss, premature delivery, and end-organ damage. In this review, we summarize the current information on the etiology of single twin demise, the pathophysiology of injury to the surviving twin, and the preventive and secondary management strategies.