Acute Renal Failure Associated with Barium Chloride Poisoning

Brief Reports1 August 1981Acute Renal Failure Associated with Barium Chloride PoisoningSTEPHEN F. WETHERILL, M.D., MICHAEL J. GUARINO, M.D., ROBERT W. COX, M.D.STEPHEN F. WETHERILL, M.D., MICHAEL J. GUARINO, M.D., ROBERT W. COX, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-95-2-187 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptBarium salts are an infrequent cause of poisoning. Because the acid-soluble barium salts (acetate, carbonate, chloride, hydroxide, nitrate, and sulfide) are highly toxic, fatalities have occurred. Although heavy metals have been a well-known cause of acute renal failure, barium salts have not been implicated previously. This case report describes the occurrence of acute renal failure after ingestion of barium chloride.A 52-year-old male research chemist was admitted to the Wilmington Medical Center with the chief complaint of diarrhea and weakness. He had been "spree drinking" laboratory ethanol for the past week when, despondent, he ingested 1 teaspoonful of barium chloride...References1. SMITHGOSSELIN RR. Current concept about the treatment of selected poisonings. Annu Rev Pharmacol Toxicol. 1976;16:189-99. CrossrefMedlineGoogle Scholar2. ROZABERMAN OL. The pathophysiology of barium: hypokalemic and cardiovascular effects. J Pharmacol Exp Ther. 1971;177:433-9. MedlineGoogle Scholar3. POLSONTATTERSALL CR. Clinical Toxicology. 2nd ed. Philadelphia: J. B. Lippincott; 1969:265-7. Google Scholar4. GOSSELINHODGESMITHGLEASON RHRN. Clinical Toxicology of Commercial Products. 4th ed. Baltimore: Williams & Wilkins; 1976:57-9. Google Scholar5. ISSELBACHERADAMSBRAUNWALDPETERSDORFWILSON KRERT. Harrison's Principles of Internal Medicine. 9th ed. New York; McGraw-Hill; 1980:955. Google Scholar6. GOODMANGILMAN LA. The Pharmacological Basis of Therapeutics. 5th ed. New York; MacMillan; 1975:791. Google Scholar7. ARENA J. Poisoning. 4th ed. Springfield: Charles C Thomas Publishers; 1979:173. Google Scholar8. BERNING J. Hypokalemia of barium poisoning. Lancet. 1975;1:110. Letter. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. 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