Key result
Inhibition of nitric oxide synthase and prostaglandins significantly abrogated the suppression of lymphocyte proliferation in spleen cells from mice with acute blood-stage malaria.
Population
C57BL/6 mice during blood-stage Plasmodium chabaudi AS infection
Comparison
In vitro addition of NO synthase inhibitors… vs Control cultures without inhibitors or generators
Design
Preclinical
Authors
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Implicates nitric oxide and prostaglandins in malaria immunosuppression in mice; leaves open relevance to human disease and therapy.
Increased nitric oxide production by macrophages contributes to immunosuppression associated with blood-stage malaria.
Ahvazi et al. (1995) studied Blood-stage malaria (Plasmodium chabaudi AS infection). Nitric oxide synthase inhibitors (L-NMMA or aminoguanidine) and/or prostaglandin inhibitor (indomethacin) vs. Control (no inhibitors) was evaluated on Suppression of lymphocyte proliferation in response to mitogens and specific antigen. Inhibition of nitric oxide synthase and prostaglandins significantly abrogated the suppression of lymphocyte proliferation in spleen cells from mice with acute blood-stage malaria.