Apparent Interaction between Nefazodone and Cyclosporine

Letters1 September 1996Apparent Interaction between Nefazodone and CyclosporineKaren M. Helms-Smith, PharmD, Stephen L. Curtis, MD, and Randy C. Hatton, PharmD, BCPSKaren M. Helms-Smith, PharmDGainesville Veterans Affairs Medical Center, Gainesville, FL 32608University of Florida, Gainesville, FL 32608, Stephen L. Curtis, MDGainesville Veterans Affairs Medical Center, Gainesville, FL 32608University of Florida, Gainesville, FL 32608, and Randy C. Hatton, PharmD, BCPSGainesville Veterans Affairs Medical Center, Gainesville, FL 32608University of Florida, Gainesville, FL 32608Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-125-5-199609010-00026 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Nefazodone is the newest antidepressant agent to be approved in the United States. This agent has been shown in vitro to be a potent inhibitor of the cytochrome P-450 system, specifically of IIIA4. Several critical drug interactions involving this isozyme are listed in the product information for nefazodone, including interactions with terfenadine, astemizole, triazolam, and alprazolam. Cyclosporine is metabolized through IIIA4, but this fact is not specifically noted in the package insert. The following case report suggests that a clinically significant drug interaction exists between nefazodone and cyclosporine.A 23-year-old man who had received a kidney transplant ...REFERENCE1. Ciraulo DA, Shader RL, Greenblatt DJ. SSRI drug–drug interactions. In: Ciraulo DA, Shader RL, Greenblatt DJ, Creelman W. Drug Interactions in Psychiatry. 2d ed. Baltimore: Williams & Wilkins; 1995:66. Google Scholar Author, Article, and Disclosure InformationAuthors: Karen M. Helms-Smith, PharmD; Stephen L. Curtis, MD; Randy C. Hatton, PharmD, BCPSAffiliations: Gainesville Veterans Affairs Medical Center, Gainesville, FL 32608University of Florida, Gainesville, FL 32608 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byGesamtliteraturverzeichnisCiclosporinDrug Interactions in Solid Organ Transplant RecipientsIMMUNE MODULATORSGLUCOCORTICOIDS AND DISEASE – MODIFYING ANTIRHEUMATIC DRUGSDrug interactions in transplant patients: what everyone should knowAnti-depressive Therapies After Heart TransplantationCiclosporinUse of Antidepressant Drugs in Transplant RecipientsDrug Therapy in Transplant RecipientsTreatment of Anxiety and Depression in Transplant PatientsNefazodone Inhibits Methylprednisolone Disposition and Enhances its Adrenal-Suppressant EffectLack of Citalopram Effect on the Pharmacokinetics of CyclosporineNefazodone and cyclosporine drug–drug interactionDRUG–DRUG INTERACTIONS IN PEDIATRIC PSYCHOPHARMACOLOGYLack of Antidepressant-Cyclosporine Pharmacokinetic InteractionsDrugs acting on the immune systemCyclosporin interaction 1 September 1996Volume 125, Issue 5Page: 424KeywordsAttentionDatabasesDrug informationDrug interactionsDrugsImmunosuppressivesInpatientsRenal transplantationSuicideToxicity ePublished: 15 August 2000 Issue Published: 1 September 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...